Our work


We are collaborating on clinical trials for a new treatment for this sometimes fatal common infection


What is strongyloidiasis?

Strongyloidiasis is a soil-transmitted helminth infection caused by strongyloides stercoralis. The WHO estimates that up to 100 million people, particularly children, are infected with this parasitic worm. The causative worm has a different lifecycle from other soil-transmitted helminths and infection can be fatal.


Why are we targeting this disease?


people, particularly children, are infected


public health strategies for controlling this disease are active at the global level


Children are particularly vulnerable to this infection


Transmission stages of Onchocerca volvulus



Treatment options are limited, with ivermectin, an anti-parasitic, being the medicine of choice, while other anthelmintic medicines such as albendazole and mebendazole, which limit the parasite’s absorption of sugar, lack sufficient efficacy as a single dose.  

MDGH is collaborating in clinical trials of moxidectin as a treatment for strongyloidiasis in Cambodia and Laos led by the Swiss Tropical and Public Health Institute, Switzerland.

Moxidectin project websites

Moxidectin icon showing 3 blue tablets

Moxidectin for accelerating onchocerciasis elimination

A paediatric dose-finding study, a phase 3b trial comparing efficacy and safety of annual and biannual moxidectin or ivermectin treatment and mathematical modelling of moxidectin and ivermectin based elimination strategies to support country policy decisions.

Moxidectin icon showing 3 blue tablets

Treatment for all

Developing a paediatric formulation moxidectin for neglected infectious diseases.


Help us treat this disease

Interested in supporting us or developing a partnership?

Get in touch

Take a look at the research and development work

Disease areas

Primarily affecting the lungs, tuberculosis remains the leading cause of infectious death worldwide.


A debilitating and disfiguring disease found in 31 African countries and beyond.

River blindness

An infectious skin condition affecting more than 200 million people at any one time.


A painful and debilitating disease of the lymph system affecting over 50 million people at any one time.

Lymphatic filariasis

A soil-transmitted infection affecting up to 100 million people, particularly children.


A chronic infectious disease which may cause skin lesions and nerve damage found in 127 countries.


Among the most common of all infections with an estimated 1.5 billion people infected worldwide.

Soil-transmitted helminth infections