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DISEASE INFORMATION

Tuberculosis

We are working on a more effective treatment for one of the leading causes of infectious deaths worldwide

OVERVIEW

What is tuberculosis?

Tuberculosis is an infection that primarily affects the lungs, but can disseminate to any part of the body, such as the kidney, spine and brain. It is caused by the bacteria Mycobacterium tuberculosis. Despite being both a preventable and curable disease, it is the leading cause of infectious death worldwide. While tuberculosis can be found anywhere in the world, most people who contract tuberculosis are in low- and middle-income countries.

THE STATS

Why are we targeting this disease?

10M

people (est.) diagnosed with TB disease in 2019

1M+

children diagnosed in 2019

Source:

World Health Organization. WHO Tuberculosis fact sheet.

1.4M

people died of TB in 2019

INFOGRAPHIC

Transmission stages of Onchocerca volvulus

WHAT we're DOING

CC-11050 (also known as AMG 634)

Current treatment regimens for tuberculosis require patients to undergo daily multidrug treatment for up to two years, in the worst-case scenario. While effective, the complexity of the treatment along with social factors (such as accessibility) can lead to poor compliance, drug resistance and treatment failure. Multidrug-resistant tuberculosis remains a public health emergency: of the 10 million new cases in 2019, over 200,000 were multidrug-resistant.

Most people infected with Mycobacterium tuberculosis do not develop symptoms. People with weakened immune systems are at much higher risk of developing serious disease. While some antibacterial strategies are effective against tuberculosis, there are few immunomodulatory treatments – that is, those that modify the body’s immune response.

CC-11050 is a selective inhibitor of the enzyme PDE4 found in monocytes and macrophages and other cells of the innate immune response. PDE4 inhibitors are immunomodulators that down-regulate the production of pro-inflammatory factors and up-regulate the anti-inflammatory interleukin-10.

We are investigating the potential for CC-11050 in the treatment of tuberculosis in a Phase 2b clinical trial sponsored by the Aurum Institute, having completed proof of concept in a Phase 2a study sponsored by the Aurum Institute and funded by the Bill and Melinda Gates Foundation.

pipeline

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Take a look at the research and development work

Disease areas

Primarily affecting the lungs, tuberculosis remains the leading cause of infectious death worldwide.

Tuberculosis

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